Neural Stem Cells And Autism

In neural stem cells contributes to deficits in neuronal maturation.

Neural stem cells and autism.

Neural stem cells nscs derived from ptenm3m4 mice have higher stemness characteristics. As the cells grew into 3 d organoids those derived from people with asd were bigger. No one knows why but people with autism spectrum disorder often experience a period of accelerated brain growth after birth. In 2014 arnold kriegstein a neural stem cell expert at the university of california san francisco told spectrum the study was a hail mary pass and that it was unlikely cord blood stem cells could reverse autism related changes to the brain during early development.

None of their explanations hold water on why it would have any. A new study by ucla researchers now demonstrates how in pregnant mice inflammation a first line defense of the immune system can trigger an excessive division of neural stem cells that can cause overgrowth in the offspring s brain. In addition a genetic program in neural stem cells that includes several genes linked to a higher risk of developing asd turned on earlier in the cells derived from people with asd than in the cells from developmentally typical donors. A nscs derived from dentate gyrus dg of wildtype left n 3 ptenwt m3m4 center n 4 and ptenm3m4 m3m4 right n 4 mice had similar morphology after 1 day and 5 days n.

Critical regulation of a ndime mef2c axis in embryonic stem cell neural differentiation and autism mingliang bai clinical and translational research center of shanghai first maternity and infant hospital shanghai key laboratory of signaling and disease research collaborative innovation center for brain science school of life sciences and.